Mechanism · Gradual Approach · Effects · Safety

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide studied for supporting delta-wave (deep) sleep, stabilizing stress hormones, and improving sleep quality without sedation. Research indicates DSIP influences GABAergic signaling, neuropeptide pathways, and HPA-axis regulation.

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Mechanism (How DSIP Works)

• Deep Sleep Enhancement
Supports increased delta-wave (slow-wave) activity → more restorative recovery phases.

• GABA Modulation
Promotes inhibitory signaling for smoother sleep onset and reduced nighttime awakenings.

• Neuropeptide & Opioid Interaction
Acts on neuropeptide systems involved in calming and stress reduction.

• Cortisol & ACTH Regulation
Helps stabilize the stress axis, improving nighttime hormonal balance.

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Dosing & Reconstitution Guide

Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL
Measurement: 1 unit = 0.01 mL ≈ 16.7 mcg
Route: Subcutaneous
Timing: Evening, 30–60 minutes before bedtime
Cycle Length: 4–8 weeks (may extend to 12 weeks with breaks)

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Standard Gradual Approach (Practical Protocol)

• Start (Week 1):
100 mcg once daily.

• Week 2:
Increase to ~150 mcg daily if well tolerated.

• Week 3:
Increase to ~200 mcg daily.

• Weeks 4–8:
Maintain 250–300 mcg daily as the target range.

• Optional Advanced Range (Experienced Users Only):
Up to 400–500 mcg daily based on individual response.
Use only if lower doses are insufficient.

This gradual progression minimizes adaptation, prevents overstimulation of neuropeptide pathways, and reduces the risk of tolerance.

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Effects (What You May Notice)

• Deeper, more restorative slow-wave sleep
Enhanced physical recovery and refreshed morning wakefulness.

• Reduced nighttime awakenings
Smoother sleep cycles and fewer disruptions.

• Stress-buffering effects
Evidence suggests DSIP may dampen hyperactive stress responses.

• Improved sleep architecture without sedation
DSIP normalizes patterns rather than “forcing” sleep like drugs.

• Better circadian stability
More regular sleep–wake timing, especially under stress or travel.

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Safety Notes

• Well tolerated at 100–300 mcg/day.
• Mild injection-site irritation may occur.
• Higher doses (>300 mcg) lack strong human data; use conservatively.
• Long-term continuous use is not well established → take breaks between cycles.
• Avoid combining with sedatives, alcohol, or CNS depressants unless supervised.